Study Progress

The data collected during EXPERTS-ALS will be reviewed regularly whilst people are still taking the drugs, not just at the end when everyone is finished. This is known as an interim analysis. The first interim analysis took place the first week of August 2026. 

If the results of an interim analysis meet the study team’s pre-agreed criteria the drug will continue to be tested in the study. It is important to remember that if a drug continues in the study, this doesn’t necessarily mean that it definitely reduces NfL levels, it just means that we need to gather more information.

If the results do not meet the criteria, the drug will not be tested further in the trial and no new participants will receive that drug. Participants who are taking a drug which is removed from the study will continue with the drug until their next scheduled visit. They will also be asked to continue to attend appointments for the full 6 months as this data will be useful, even after a drug has been removed from the trial. 

Click here to view the results of each interim analysis